Lung

Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis

L. - D. Liu, Wu, X. - Y., Tao, B. - D., Wang, N., Zhang, J., Liu, L. - D., Wu, X. - Y., Tao, B. - D., Wang, N., Zhang, J., Liu, L. - D., Wu, X. - Y., Tao, B. - D., Wang, N., and Zhang, J., Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis, vol. 15, p. -, 2016.

This study aimed to explore the protective effect of hydrogen and to investigate the underlying mechanism of its preliminary effect on the alveolar epithelial barrier function in septic rats. Forty-five male Sprague-Dawley rats were divided randomly into three groups (N = 15): control [saline injection (intraperitoneal, ip), air drawing; SA], acute lung injury group [lipopolysaccharide (LPS) injection (ip, 15 mg/kg), air drawing; LA], and acute lung injury combined with hydrogen drawing group [LPS injection (ip, 15 mg/kg), 2% hydrogen drawing; LH].

Identification of transgenic cloned dairy goats harboring human lactoferrin and methylation status of the imprinted gene IGF2R in their lungs

Y. L. Zhang, Zhang, G. M., Wan, Y. J., Jia, R. X., Li, P. Z., Han, L., Wang, F., and Huang, M. R., Identification of transgenic cloned dairy goats harboring human lactoferrin and methylation status of the imprinted gene IGF2R in their lungs, vol. 14, pp. 11099-11108, 2015.

Dairy goat is a good model for production of transgenic proteins in milk using somatic cell nuclear transfer (SCNT). However, animals produced from SCNT are often associated with lung deficiencies. We recently produced six transgenic cloned dairy goats harboring the human lactoferrin gene, including three live transgenic clones and three deceased transgenic clones that died from respiratory failure during the perinatal period. Imprinted genes are important regulators of lung growth, and may be subjected to faulty reprogramming.

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