Loss of heterozygosity

Loss of heterozygosity on chromosome 5 in Iranian esophageal cancer patients

F. Attaran-Bandarabadi, Ziaee, A. A., Yazdanbod, M., Shahpanah, M., Setayeshgar, A., and Nassiri, M., Loss of heterozygosity on chromosome 5 in Iranian esophageal cancer patients, vol. 10, pp. 2316-2325, 2011.

There is a high incidence of esophageal squamous cell carcinoma (ESCC) in Iran. Non-functionality of some tumor suppressor genes has been reported in esophageal cancer. Loss of heterozygosity on chromosome 5 has also been reported in esophageal carcinomas. We assessed loss of heterozygosity along a region of the long arm of chromosome 5 (5q), from 5q23.1 to 5q23.2, by PCR amplifying DNA fragments of tumor tissues from patients with ESCC and their corresponding normal samples.

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