LMNA gene

Association of the LMNA gene single nucleotide polymorphism rs4641 with bdilated cardiomyopathy

J. Yin, Yang, J., Ren, F. X., Sun, C. M., Li, L. D., Han, L. Y., Cai, S. L., Zhang, C. H., Zhang, Z. Q., Zhang, Z. T., and Wang, H., Association of the LMNA gene single nucleotide polymorphism rs4641 with bdilated cardiomyopathy, vol. 14, pp. 15427-15434, 2015.

Recently, studies on the pathogenesis of dilated cardiomyopathy (DCM) have focused on the underlying molecular biology and the association between single nucleotide polymorphisms (SNPs) and disease. This study was designed to explore the association between the rs4641 SNP of the LMNA gene and DCM in order to identify a new gene locus related to DCM. Polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing were employed to detect and genotype rs4641 in 198 patients with DCM and 160 healthy controls.

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