Liver regeneration

Co-expression network analysis prioritizes signaling pathways regulating liver regeneration after partial hepatectomy in rats

Y. Zhou, Xu, J. C., Xu, C. S., Zhou, Y., Xu, J. C., Xu, C. S., Zhou, Y., Xu, J. C., and Xu, C. S., Co-expression network analysis prioritizes signaling pathways regulating liver regeneration after partial hepatectomy in rats, vol. 15, p. -, 2016.

The liver has extraordinary powers of regeneration following partial hepatectomy (PH). Changes in gene expression levels play a key role in cell proliferation and differentiation during liver regeneration (LR). To understand the molecular mechanisms underlying LR, this study was designed to assess the time-dependent changes in rat hepatic gene expression. We obtained a gene expression profile of rat LR with high temporal resolution.

Fructus polygoni orentalis extract inhibited liver regeneration and proliferation of bone marrow cells of rat after partial hepatectomy

J. Y. Yang, Wang, J. S., and Liu, H. B., Fructus polygoni orentalis extract inhibited liver regeneration and proliferation of bone marrow cells of rat after partial hepatectomy, vol. 14, pp. 7671-7679, 2015.

To study the effect of fructus polygoni orentalis extract (EFPO) on liver regeneration and proliferation of bone marrow cells on rat model of partial hepatectomy, EFPO was extracted, and 60 adult male Wistar rats were divided randomly into 6 experimental groups. Rats were treated with intergastric administration (ig) with EFPO daily. All rats were euthanized 7 days after administration, and the livers and bone marrow cells were collected. The levels of taxifolin and quercetin in EFPO were 1.238 and 0.381 mg/g, respectively.

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