Liver cancer

Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression

B. S. Wang, Liu, Z., Xu, W. X., and Sun, S. L., Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression, vol. 13, pp. 5426-5440, 2014.

MicroRNAs (miRNAs) are small non-coding RNA molecules that play a fundamental role in controlling a variety of biological functions. Emerging evidence has shown that common genetic polymorphisms in miRNAs may be associated with the development of liver cancer; however, several individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of the association between functional polymorphisms in miRNAs and susceptibility to liver cancer.

Association between the EGF rs4444903 polymorphism and liver cancer susceptibility: a meta-analysis and meta-regression

Y. L. Li, Tian, Z., Zhao, L., and Zhang, C. L., Association between the EGF rs4444903 polymorphism and liver cancer susceptibility: a meta-analysis and meta-regression, vol. 13, pp. 8066-8079, 2014.

Emerging evidence suggests that a common functional polymorphism, rs4444903 (A>G), in the EGF gene might impact an individual’s susceptibility to liver cancer; however, individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationship between the EGF rs4444903 polymorphism and liver cancer risk. A literature search was conducted in the PubMed, Embase, Web of Science, and CBM databases from inception through May 1st, 2013.

Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue

C. S. Xu, Wang, G. P., Zhang, L. X., Chang, C. F., Zhi, J., and Hao, Y. P., Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue, vol. 10, pp. 3480-3513, 2011.

Liver cancer (LC) is generally characterized by malignant cell proliferation and growth; it normally develops in stages that progress from non-specific injury of the liver to liver fibrosis, liver cirrhosis, dysplasia nodules, and liver carcinoma. We used a rat model of diethylnitrosamine (DENA)-induced LC; a Rat Genome 230 2.0 Array was used to detect gene expression profile of liver tissues from male rats 5, 8, 12, 16, and 18 weeks following the beginning of DENA-induced LC.

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