Liver

Clinical research on dendritic cell vaccines to prevent postoperative recurrence and metastasis of liver cancer

T. Y. Sun, Yan, W., Yang, C. M., Zhang, L. F., Tang, H. L., Chen, Y., Hu, H. X., and Wei, X., Clinical research on dendritic cell vaccines to prevent postoperative recurrence and metastasis of liver cancer, vol. 14, pp. 16222-16232, 2015.

We aimed to evaluate dendritic cell (DC) tumor vaccines for preventing liver cancer recurrence and metastasis. DCs were induced from mononuclear cells in the peripheral blood with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin 4 (rhIL-4), followed by sensitization with lysis of autologous liver cancer cells. One hundred and sixty patients with hepatocellular carcinoma were randomly divided into two groups of 80. One group was treated postoperatively with six cycles of the DC tumor vaccine.

Akirin2 expression in response to vaccine-induced immunity in chicken

C. L. Man, Mu, W. T., Chang, Y., and Zhao, D. X., Akirin2 expression in response to vaccine-induced immunity in chicken, vol. 14, pp. 17489-17495, 2015.

Akirin2 is a nuclear factor that plays an important role in the development and regulation of innate immune response. In this study, akirin2 gene expression in several primary immune organs (liver, thymus, and bursa) of Hi-Line Brown chicken administered with the LoSota vaccine was analyzed during the various stages of increase in Newcastle disease virus antibody titer. The results revealed that akirin2 expression was significantly higher in the liver (P < 0.01) and bursa (P < 0.05) of vaccinated chicken 7 and 14 days post-immunization, respectively.

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