Liposome

Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo

Y. B. Deng, Qin, H. J., Luo, Y. H., Liang, Z. R., and Zou, J. J., Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo, vol. 14, pp. 10087-10095, 2015.

We investigated the effects of hepatitis B virus (HBV) S/C double gene loci antisense locked nucleic acid on replication and expression of HBV in hepatitis transgenic mice. HBV mice (N = 30) were randomly divided into five groups of six mice: 5% glucose solution control, empty liposome control, single-target S, single-target C, and dual-target SC groups. An antisense locked nucleic acid fragment was injected into the mice.

 Blocking the expression of the hepatitis B virus S gene in hepatocellular carcinoma cell lines with an anti-gene locked nucleic acid in vitro

Y. - B. Deng, Qin, H. - J., Luo, Y. - H., Liang, Z. - R., and Zou, J. - J.,  Blocking the expression of the hepatitis B virus S gene in hepatocellular carcinoma cell lines with an anti-gene locked nucleic acid in vitro, vol. 14, pp. 5445-5451, 2015.

The aim of this study was to investigate the effects of inhibition of the hepatitis B virus (HBV) S gene by polypurine region locked nucleic acid on viral replication in cells. We designed and synthe­sized a locked nucleic acid, phosphorothioate oligonucleotides, unmod­ified oligonucleotides, and unrelated control sequence for the hepatitis B virus S gene polypurine region.

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