Lipopolysaccharide

Toll-like receptor-4-dependence of the lipopolysaccharide-mediated inhibition of osteoblast differentiation

Y. H. Liu, Huang, D., Li, Z. J., Li, X. H., Wang, X., Yang, H. P., Tian, S. P., Mao, Y., Liu, M. F., Wang, Y. F., Wu, Y., Han, X. F., Liu, Y. H., Huang, D., Li, Z. J., Li, X. H., Wang, X., Yang, H. P., Tian, S. P., Mao, Y., Liu, M. F., Wang, Y. F., Wu, Y., Han, X. F., Liu, Y. H., Huang, D., Li, Z. J., Li, X. H., Wang, X., Yang, H. P., Tian, S. P., Mao, Y., Liu, M. F., Wang, Y. F., Wu, Y., and Han, X. F., Toll-like receptor-4-dependence of the lipopolysaccharide-mediated inhibition of osteoblast differentiation, vol. 15, p. -, 2016.

Bone fractures or bones subjected to open conduction and internal fixation are easily infected by bacteria; bacterial lipopolysaccharide (LPS) has been recognized as an important pathogenic factor affecting bone fracture healing. Therefore, the effect of LPS on bone metabolism is relevant for bone healing. In this study, we investigated the effect of LPS on the expression of Toll-like receptor (TLR)-4 (an LPS receptor) by using real-time quantitative PCR and western blotting.

Protective effect of penehyclidine hydrochloride on lipopolysaccharide-induced acute kidney injury in rat

H. J. Cao, Yu, D. M., Zhang, T. Z., Zhou, J., Chen, K. Y., Ge, J., and Pei, L., Protective effect of penehyclidine hydrochloride on lipopolysaccharide-induced acute kidney injury in rat, vol. 14, pp. 9334-9342, 2015.

We aimed to observe the effect of penehyclidine hydrochloride (PHC) on lipopolysaccharide (LPS)-induced acute kidney injury in rats and expression of tight junction proteins ZO-1 and occludin. Adult male Sprague-Dawley (SD) rats were divided randomly (N = 10) into control group (C), LPS group (LPS), low-dose PHC group (L-PHC), and high-dose PHC group (H-PHC). All rats, except C group, received a vena caudalis injection of 5.0 mg/kg LPS; after 30 min, rats in L-PHC and H-PHC groups received a vena caudalis injection of 0.3 and 0.9 mg/kg PHC.

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