Leukemia

Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway

Z. G. Peng, Liu, D. C., Yao, Y. B., Feng, X. L., Huang, X., Tang, Y. L., Yang, J., Wang, X. X., Peng, Z. G., Liu, D. C., Yao, Y. B., Feng, X. L., Huang, X., Tang, Y. L., Yang, J., and Wang, X. X., Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway, vol. 15, p. -, 2016.

Paclitaxel (PTX) is a mitotic inhibitor widely used in chemotherapy for many types of cancers, including solid tumors and hematological malignancies. However, the molecular basis of the anti-proliferation activity of PTX is not fully understood. In this paper, we focused on the role of c-Jun N-terminal kinase (JNK) pathways in PTX-induced apoptosis and proliferation inhibition.

Expression differences in TEL-AML1 fusion gene in leukemia glucocorticoid-sensitive and -resistant cell lines

X. W. Wang and Xu, Y. H., Expression differences in TEL-AML1 fusion gene in leukemia glucocorticoid-sensitive and -resistant cell lines, vol. 14, pp. 7883-7893, 2015.

We investigated the expression differences of the TEL-AML1 fusion gene in a leukemia glucocorticoid (GC)-sensitive cell line (CEM) and a GC-resistant cell line (Jurkat). Changes in TEL-AML1 expression before and after GC exposure were analyzed. Expression of GC-sensitive and GC-resistant leukemia cells following initial diagnosis and during treatment was simulated. Leukemia cells were divided into a GC-unexposed or a GC-exposed group.

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