Leptin

Study of the correlation between growth hormone deficiency and serum leptin, adiponectin, and visfatin levels in adults

Z. - P. Li, Zhang, M., Gao, J., Zhou, G. - Y., Li, S. - Q., and An, Z. - M., Study of the correlation between growth hormone deficiency and serum leptin, adiponectin, and visfatin levels in adults, vol. 13, pp. 4050-4056, 2014.

We aimed to determine the significance and changes in leptin, adiponectin (ADP), and visfatin levels in adults with growth hormone deficiency (GHD). Forty adults (19 men, 21 women) who had been diagnosed with GHD comprised the observation group, while 36 healthy adults (18 men, 18 women) were used as the control group. Fasting venous blood was collected to detect leptin, ADP, and visfatin levels. There was no statistically significant difference (P > 0.05) between the GHD group and the control group in terms of gender ratio, age, and body mass index.

Comparative study of leptin and leptin receptor gene expression in different swine breeds

S. E. Georgescu, Manea, M. A., Dinescu, S., and Costache, M., Comparative study of leptin and leptin receptor gene expression in different swine breeds, vol. 13, pp. 7140-7148, 2014.

Leptin is an important regulator of appetite, energy metabolism, and reproduction and is mainly synthesized in the adipocytes and then secreted into the bloodstream. The leptin receptor was classified as type I cytokine receptor due to its structural homology with IL-6 receptors and the signaling pathways in which they are both involved.

Improved gastric emptying in diabetic rats by irbesartan via decreased serum leptin and ameliorated gastric microcirculation

L. He, Sun, Y., Zhu, Y., Ren, R., Zhang, Y., and Wang, F., Improved gastric emptying in diabetic rats by irbesartan via decreased serum leptin and ameliorated gastric microcirculation, vol. 13, pp. 7163-7172, 2014.

Diabetic gastroparesis (DG) is a common clinical complication of diabetes mellitus. Leptin may cause delayed gastric emptying in the central and peripheral pathways. Microcirculatory disturbances in the stomach make gastric smooth muscles and nerves hypoxic-ischemic, thereby impairing gastric motility. Irbesartan is an angiotensin II (ATII) receptor blocker that indirectly decreases serum leptin levels and improves blood vessel endothelia.

High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia

S. Wang, Qiao, F. Y., and Feng, L., High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia, vol. 12, pp. 2416-2422, 2013.

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and Lys656Asn + Asn656Asn frequencies in the LEPR gene were significantly more prevalent in preeclampsia mothers than in controls (P

A novel missense mutation T101N in the melanocortin-4 receptor gene associated with obesity

S. Buchbinder, Bärtsch, U., Müller, M., Zorn, M., Nawroth, P. P., and Schilling, T., A novel missense mutation T101N in the melanocortin-4 receptor gene associated with obesity, vol. 10, pp. 1042-1049, 2011.

Mutations in the melanocortin-4 receptor (MC4R) are associated with severe obesity, independent of their effect on cortisol or thyroid-stimulating hormone levels. We examined a morbidly obese male (BMI = 62 kg/m2) with a binge-eating disorder and eight family members for mutations in the MC4R gene and potential differences in leptin levels. Fifty healthy individuals served as controls. Sequence analysis revealed a novel heterozygous missense mutation (c.302 C>A, p.T101N) located in the second transmembrane domain of the receptor, which was not detected in controls.

Leptin mRNA expression in the rat mammary gland at different activation stages

Y. Y. Wang, Wang, Y. L., Li, H. P., Zhu, H. S., Jiang, Q. D., Zhang, L., Wang, L. F., Han, L. Q., Zhong, K., Guo, Y. J., Lu, W. F., Li, H. J., and Yang, G. Y., Leptin mRNA expression in the rat mammary gland at different activation stages, vol. 10, pp. 3657-3663, 2011.

Leptin is expressed in various tissues, suggesting that this protein is effective not only at the central nervous system level, but also peripherically. Recent studies have shown leptin production by other tissues, including the placenta, stomach, and mammary tissues, but there is no information available concerning expression levels of leptin in the rat mammary gland at different activation stages. We used semi-quantitative RT-PCR to investigate leptin mRNA expression levels in the rat mammary gland at different activity stages.

Obese gene polymorphism in Pietrain and large white pigs after a divergent selection

A. C. P. Silveira, Antunes, R. C., Almeida, J. F., Braga, T. F., Freitas, P. F. A., César, A. S. M., César, A. S. M., and Guimarães, E. C., Obese gene polymorphism in Pietrain and large white pigs after a divergent selection, vol. 7, pp. 1217-1222, 2008.

The aim of the present study was to identify polymorphisms in the leptin gene of 112 pigs and compare the maternal and paternal lineage of Pietrain and Large White breeds that underwent a divergent selection for over 30 years. DNA samples extracted from the blood of these animals were amplified by polymerase chain reaction and genotyped by restriction fragment length polymorphism using the restriction enzyme HinfI. The data were statistically analyzed by the chi-square test.

Effect of leptin gene polymorphisms on growth, slaughter and meat quality traits of grazing Brangus steers

P. M. Corva, Macedo, G. V. Fernández, Soria, L. A., J. Mazzucco, P., Motter, M., Villarreal, E. L., Schor, A., Mezzadra, C. A., Melucci, L. M., and Miquel, M. C., Effect of leptin gene polymorphisms on growth, slaughter and meat quality traits of grazing Brangus steers, vol. 8, pp. 105-116, 2009.

Leptin is a hormone that affects the regulation of feed intake, energy balance and body composition in mammals. Several polymorphisms in the bovine leptin gene have been associated with phenotypic variance of these traits. We evaluated two known single nucleotide polymorphisms (SNPs) in the leptin gene of 253 grazing Brangus steers. Brangus is a 5/8 Angus-3/8 Brahman composite. Data were collected during two consecutive growth/fattening cycles from two farms in southeast Buenos Aires province, Argentina.

Association of single nucleotide polymorphisms with carcass traits in Nellore cattle

J. B. S. Ferraz, Pinto, L. F. B., Meirelles, F. V., Eler, J. P., de Rezende, F. M., Oliveira, E. C. M., Almeida, H. B., Woodward, B., and Nkrumah, D., Association of single nucleotide polymorphisms with carcass traits in Nellore cattle, vol. 8, pp. 1360-1366, 2009.

The association between two single nucleotide polymorphisms (SNPs), T945M and UCP1SNP1, with hot carcass weight (HCW, kg, N = 618), longissimus dorsi muscle area (REA, cm2, N = 633), and backfat thickness (BF, mm, N = 625), measured in Nellore cattle in Brazil, was evaluated. Likelihood ratio tests were used to evaluate reduced (fixed effects of general mean, contemporary group, yearling weight, age at slaughter, and random effect of infinitesimal genetic value) and full model (reduced model effects plus quantitative trait locus effects).

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