Lentivirus

Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299

G. M. Chen, Ding, R. F., Tan, Y. D., Pan, X. B., Jiang, G. M., He, J. F., Lin, S. H., Liu, C., and Jia, Y., Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299, vol. 14, pp. 4005-4014, 2015.

Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies examining the function of CKIP1 in cancer cells have been performed. The present study aimed to investigate the role of CKIP1 in lung cancer.

Effect of lentivirus-mediated RNA interference of APC-Cdh1 expression on spinal cord injury in rats

Y. - H. Qi, Yao, W. - L., Zhang, C. - H., and Guo, Y. - Q., Effect of lentivirus-mediated RNA interference of APC-Cdh1 expression on spinal cord injury in rats, vol. 13, pp. 1366-1372, 2014.

This study investigated cadherin-1 (Cdh1) expression in the sensorimotor cortex of rats after spinal cord injury (SCI). The repairing effect of Cdh1 was evaluated by silencing its expression with lentivirus-mediated RNAi. Twenty male Sprague-Dawley (SD) rats were randomly divided into a normal group and an operation group. Rats of the operation group were given SCI by the Allen method (T10-T11). Cdh1 expression in the sensorimotor cortex was examined by quantitative real-time polymerase chain reaction (PCR) and Western blot analysis.

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