Leishmaniasis

Leishmania (Viannia) braziliensis in dogs in Brazil: epidemiology, co-infection, and clinical aspects

F. S. Carvalho, Wenceslau, A. A., Albuquerque, G. R., Munhoz, A. D., Gross, E., Carneiro, P. L. S., Oliveira, H. C., Rocha, J. M., Santos, I. A., and Rezende, R. P., Leishmania (Viannia) braziliensis in dogs in Brazil: epidemiology, co-infection, and clinical aspects, vol. 14, pp. 12062-12073, 2015.

Leishmaniasis is an endemic disease present in 98 countries. In Brazil, the northeast region accounts for approximately half of the cases in humans, and has experienced an increased number of positive cases in dogs. In this study, we investigated the epidemiology of canine leishmaniasis in the city of Ilhéus, Bahia, using serological and molecular techniques and evaluated the possible environmental risk factors and associated clinical signs. Blood samples were collected from 560 dogs in urban and peri-urban areas in Ilhéus, northeastern Brazil.

Association between HLA-C*04 and American cutaneous leishmaniasis in endemic region of southern Brazil

R. C. Ribas-Silva, Ribas, A. D., Ferreira, E. C., Silveira, T. G. V., and Borelli, S. D., Association between HLA-C*04 and American cutaneous leishmaniasis in endemic region of southern Brazil, vol. 14, pp. 14929-14935, 2015.

Leishmaniasis is a parasitic infectious disease with global repercussions. American cutaneous leishmaniasis (ACL) is endemic in southern Brazil and its pathogenesis varies according to parasite species, immune response, and host genetics. In terms of immunogenetics, many host genes, including HLA (human leukocyte antigen), could be involved in susceptibility to and protection against ACL. Accordingly, the aim of this study was to investigate the association between HLA class I genes (HLA-A, -B, and -C) and ACL in an endemic region of southern Brazil.

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