Leishmania

Intraflagellar transport complex in Leishmania spp. In silico genome-wide screening and annotation of gene function

J. J. S. Gouveia, Vasconcelos, E. J. R., Pacheco, A. C. L., Araújo-Filho, R., Maia, A. R. S., Kamimura, M. T., Costa, M. P., Viana, D. A., Costa, R. B., Maggioni, R., and Oliveira, D. M., Intraflagellar transport complex in Leishmania spp. In silico genome-wide screening and annotation of gene function, vol. 6, pp. 766-798, 2007.

Flagella are constructed and maintained through the highly conserved process of intraflagellar transport (IFT), which is a rapid movement of particles along the axonemal microtubules of cilia/flagella. Particles that are transported by IFT are composed of several protein subunits comprising two complexes (A and B), which are conserved among green algae, nematodes, and vertebrates.

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