L-FABP

Role of a liver fatty acid-binding protein gene in lipid metabolism in chicken hepatocytes

G. L. Gao, Na, W., Wang, Y. X., Zhang, H. F., Li, H., and Wang, Q. G., “Role of a liver fatty acid-binding protein gene in lipid metabolism in chicken hepatocytes”, vol. 14, pp. 4847-4857, 2015.

This study investigated the role of the chicken liver fatty acid-binding protein (L-FABP) gene in lipid metabolism in hepatocytes, and the regulatory relationships between L-FABP and genes related to lipid metabolism. The short hairpin RNA (shRNA) interference vector with L-FABP and an eukaryotic expression vector were used. Chicken hepatocytes were subjected to shRNA-mediated knockdown or L-FABP cDNA overexpression.

Association of T1740C polymorphism of L-FABP with meat quality traits in Junmu No. 1 white swine

Y. H. Zhang, Dai, L. S., Ma, T. H., Wang, S. Z., Guo, J., Li, F. J., Zhang, S. M., Sun, B. X., Liu, D. F., Gao, Y., and Zhang, J. B., “Association of T1740C polymorphism of L-FABP with meat quality traits in Junmu No. 1 white swine”, vol. 12, pp. 235-241, 2013.

This study was designed to investigate a single nucleotide polymorphism in intron 1 of the liver fatty acid-binding protein (L-FABP) gene in 156 Junmu No. 1 white swine using PCR-single-strand conformational polymorphism. The association between the polymorphism and meat quality traits was also studied. The cloning and sequencing results indicated that the polymorphism in intron 1 was due to a T→C mutation at position 1740 of L-FABP, yielding three genotypes (TT, TC, and CC).

Differential expression of L-FABP and L-BABP between fat and lean chickens

Q. Zhang, Shi, H., Liu, W., Wang, Y., Wang, Q., and Li, H., “Differential expression of L-FABP and L-BABP between fat and lean chickens”, vol. 12, pp. 4192-4206, 2013.

Liver fatty acid-binding protein (L-FABP) and liver bile acid-binding protein (L-BABP), in the liver intra-cytoplasm of chicken, are members of the fatty acid-binding protein subfamily. This study was designed to analyze and compare L-FABP and L-BABP expression levels between fat and lean lines in chicken liver tissue, and to determine the relationship between their expression and lipid metabolism. Real-time polymerase chain reaction (PCR) and Western blotting were used to detect the mRNA and protein expression in liver tissue between the lean and fat lines.

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