Killing effect

Effects of CD3McAb and rhIL-2 activated bone marrow on the killing and purging of leukemia cells

X. C. Wei, Yang, D. D., Han, X. R., Zhao, Y. A., Li, Y. C., Zhang, L. J., and Wang, J. J., Effects of CD3McAb and rhIL-2 activated bone marrow on the killing and purging of leukemia cells, vol. 14, pp. 18287-18292, 2015.

We investigated the roles of CD3McAb and rhIL-2 activated bone marrow in the killing and purging of leukemia cells. Cytotoxicity of activated bone marrow was detected with MTT assay. CFU-GM level in activated bone marrow and the destruction of leukemia cells were measured using the semi-solid cell culture. Immune activation markers in activated bone marrow were detected by indirect immunofluorescence assay. Bone marrow activated by CD3McAb and rhIL-2 displayed significantly upregulated the killing and purging abilities on the leukemia cell line K562 and HL-60.

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