Killer cell immunoglobulin-like receptor

KIR gene polymorphism study in the Uygur population in Xinjiang, China

G. - Y. Lin and Wang, Y. - B., KIR gene polymorphism study in the Uygur population in Xinjiang, China, vol. 13, pp. 1813-1822, 2014.

We analyzed killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and genotype and haplotype characteristics in the Uygur population, a non-nomadic ethnic group found in Xinjiang, China, to provide a basis for studies on relationships between KIRs and diseases in this group. Sequence-specific primer PCR was used to detect the KIR gene in 84 Uygur individuals. A standard genotype and haplotype analysis was conducted using Hsu’s standards. Sixteen KIR genes were detected; the 3DL3, 2DL4, 3DL2 genes were found in all individuals.

Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han

C. Lu, Shen, Y. - J., Deng, Y. - F., Wang, C. - Y., Fan, G., Liu, Y. - Q., Zhao, S. - M., Zhang, B. - C., Zhao, Y. - R., Wang, Z. - E., Zhang, C. - Z., and Lu, Z. - M., Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han, vol. 11, pp. 1370-1378, 2012.

Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis patients and 110 healthy controls using sequence-specific primer PCR analysis of genomic DNA.

Subscribe to Killer cell immunoglobulin-like receptor