KEGG pathway

Analysis of key genes and pathways involved in acute lung injury in a mouse model

Q. H. Han, Han, N., Liu, Y. Z., Jin, Q. H., Lu, Q. Y., and Li, Z. C., Analysis of key genes and pathways involved in acute lung injury in a mouse model, vol. 13, pp. 4591-4598, 2014.

A mouse model of acute lung injury (ALI) was chosen in this study to explore the key genes and pathways involved in the process of ALI with microarray technology. Gene expression microarray data were downloaded from the Gene Expression Omnibus database. Mice from the experimental group were further divided into 6 subgroups, which received octadecenoate treatments for 1, 1.5, 3, 4, 18, and 24 h. Differentially co-expressed genes were screened to uncover the pathogenesis of ALI. Almost all of the differentially co-expressed genes were identified at two times: 1.5 and 3 h.

Gene expression profile and enrichment pathways in different stages of bladder cancer

Z. - Q. Fang, Zang, W. - D., Chen, R., Ye, B. - W., Wang, X. - W., Yi, S. - H., Chen, W., He, F., and Ye, G., Gene expression profile and enrichment pathways in different stages of bladder cancer, vol. 12, pp. 1479-1489, 2013.

Bladder cancer is a highly heterogeneous neoplasm. We examined the gene expression profile in 3 bladder cancer stages (Ta, T1, T2) using expression microarray analysis of 40 bladder tumors. Differentially expressed genes were found by the t-test, with ANXA5, ATP6V1B2, CTGF, GEM, IL13RA1, and LCP1); 5 genes were up-regulated at the Ta-T1 stage, but down-regulated at the T1-T2 stage (ACPP, GNL1, RIPK1, RAPGEF3, and ZER1).

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