Juglone

Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway

Y. B. Ji, Xin, G. S., Qu, Z. Y., Zou, X., Yu, M., Ji, Y. B., Xin, G. S., Qu, Z. Y., Zou, X., and Yu, M., Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway, vol. 15, p. -, 2016.

This study investigated the nature and mechanism of juglone-induced apoptosis in the human breast cancer cell line MCF-7. The inhibitory effect of juglone on MCF-7 cell growth was evaluated by the dimethylthiazol tetrazolium assay. Morphological apoptotic changes were characterized using an inverted microscope, Hoechst 33258 fluorescence staining, and Giemsa staining. The rate of cell apoptosis, intracellular levels of reactive oxygen species (ROS), and mitochondrial membrane potential were detected using flow cytometry.

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