JAK2V617F mutation

Correlative study between the JAK2V617F mutation and thrombosis in patients with myeloproliferative neoplasm

Z. C. Li, Fu, H. J., Wang, Z. M., Yang, S., Xu, H. Z., Li, Z. C., Fu, H. J., Wang, Z. M., Yang, S., and Xu, H. Z., Correlative study between the JAK2V617F mutation and thrombosis in patients with myeloproliferative neoplasm, vol. 15, p. -, 2016.

In this study, we investigated the correlation between the JAK2V617F mutation and thrombosis in patients with myeloproliferative neoplasm (MPN) using real-time fluorescence quantitative PCR. The incidence of thrombus was monitored and blood and coagulation were routinely assayed in patients with MPN. The JAK2V617F mutation was found in 8/68 individuals in the control group (11.8%); it was expressed in 44/68 patients with MPN (64.7%), suggesting that the rate of this mutation was significantly higher in patients with MPN than that in the control group.

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