Invasion

Expression of microRNA-210 in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion

T. Y. Liu, Zhang, H., Du, S. M., Li, J., Wen, X. H., Liu, T. Y., Zhang, H., Du, S. M., Li, J., and Wen, X. H., “Expression of microRNA-210 in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion”, vol. 15, p. -, 2016.

This study investigated the expression of microRNA-210 (miR-210) in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion. Thirty-two renal carcinoma patients in our hospital were selected as the study group and 32 people receiving a physical examination were selected as the control group. miR-210 expression in the serum of renal carcinoma patients and in healthy subjects was quantified by real-time polymerase chain reaction.

Regulatory role of microRNA184 in osteosarcoma cells

G. R. Yin, Wang, Q., Zhang, X. B., and Wang, S. J., “Regulatory role of microRNA184 in osteosarcoma cells”, vol. 14, pp. 14246-14252, 2015.

Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expressed in multiple tumors, and is involved in tumor cell growth, differentiation, invasion, and metastasis. Nevertheless, the role of miR-184 in osteosarcoma cells remains unknown.

Influence of suppression of CapG gene expression by siRNA on the growth and metastasis of human prostate cancer cells

B. K. Li, Guo, K., Li, C. Y., Li, H. L., Zhao, P. P., Chen, K., and Liu, C. X., “Influence of suppression of CapG gene expression by siRNA on the growth and metastasis of human prostate cancer cells”, vol. 14, pp. 15769-15778, 2015.

This study investigated CapG gene expression in prostate cancer cell lines; in addition, we explored the effects of CapG suppression on DU145 cell growth, and the underlying mechanism with which CapG affects DU145 cell growth and invasiveness. The expression of CapG and 18 related genes in DU145 cells was analyzed by flow cytometry, quantitative polymerase chain reaction (qPCR), CCK8 assay, western blot, and the trans-well assay. DU145 cells were transfected with designed small interfering RNA (siRNA). CapG expression was quantified by qPCR and western blot.

Regulating effect of MMP-9 and TIMP-1 in pi­tuitary adenoma invasion

J. H. Mao, Guo, H., Si, N., Qiu, L., Guo, L. F., Sun, Z. S., Xiang, Y., Yang, X. H., Zhao, W. G., and Zhang, W. C., “Regulating effect of MMP-9 and TIMP-1 in pi­tuitary adenoma invasion”, vol. 14, pp. 17091-17098, 2015.

Pituitary adenomas can cause endocrine disorder and organ damage, with some aggressive ones leading to a high postoperative recurrence rate. The occurrence and development of these type of tumors is closely related with matrix metalloproteinases (MMPs) and endogenous specific tissue inhibitor of MMPs (TIMPs). In this study, the relationship between pituitary adenoma invasion and the changes in MMP-8 and TIMP-1 expressions is analyzed.

Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma

L. Q. Zhang, Sun, S. L., Li, W. Y., Feng, Z., Xu, X. Y., Zhuang, Q. S., and Fang, J., “Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma”, vol. 14, pp. 18315-18324, 2015.

Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The expression level of miR-874 was quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR) in human osteosarcoma cell lines and tissues.

Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Dong, T. L., “Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression”, vol. 14, pp. 7529-7537, 2015.

Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion assay. Quantitative polymerase chain reaction (qPCR) was used to assess microRNA-133a (miR-133a) expression.

Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Yue, X. Q., “Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression”, vol. 14, pp. 8117-8124, 2015.

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel invasion assay. Real-time polymerase chain reaction (PCR) was used to assess microRNA (miR)-221 expression.

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