intrinsically bent DNA

Ability of HMGB1 protein to bind to intrinsically bent and non-bent DNA sites in the AMPD2 gene amplicon

K. J. R. Passos, Fiorini, A., Rosado, F. R., Freitas, D. V. B., Neto, Q. A. Lima, Júnior, J. R. Pattaro, Gaspar, V. P., Fernandez, M. A., Passos, K. J. R., Fiorini, A., Rosado, F. R., Freitas, D. V. B., Neto, Q. A. Lima, Júnior, J. R. Pattaro, Gaspar, V. P., and Fernandez, M. A., Ability of HMGB1 protein to bind to intrinsically bent and non-bent DNA sites in the AMPD2 gene amplicon, vol. 15, p. -, 2016.

HMGB-like proteins are architectural chromatin factors, and their function is heavily dependent on their ability to interact with DNA (especially non-canonical DNA structures). HMGB1 is involved in many DNA processes, and dysregulation of HMGB protein expression has profound effects on cellular transcription, resulting in severe developmental defects as well as cancer. During DNA replication, elements that form the origin are still not well defined in metazoans.

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