Intracranial aneurysm

Association between the hsa-miR-146a rs2910164 functional polymorphism with susceptibility to intracranial aneurysm

X. T. Sima, Xu, J. G., Li, J., and You, C., “Association between the hsa-miR-146a rs2910164 functional polymorphism with susceptibility to intracranial aneurysm”, vol. 14, pp. 7680-7686, 2015.

Vascular inflammation has been shown to be involved in the pathogenesis of intracranial aneurysms (IA). MiRNAs are key molecules that participate in the regulation of many important biological processes including inflammation. Studies on the hsa-miR-146a rs2910164 polymorphism and its association with different inflammatory related diseases have engendered inconsistent results, and until now, there have been no reports on the association between this polymorphism and the susceptibility to IA.

Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population

L. T. Zhang, Wei, F. J., Zhao, Y., Zhang, Z., Dong, W. T., Jin, Z. N., Gao, F., Gao, N. N., Cai, X. W., Li, N. X., Wei, W., Xiao, F. S., Yue, S. Y., Zhang, J. N., Yang, S. Y., Li, W. D., and Yang, X. Y., “Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population”, vol. 14, pp. 6865-6878, 2015.

Few studies have examined the genes related to risk fac­tors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the association of IA and IA rup­ture with risk factors. Twenty-eight single nucleotide polymorphisms (SNPs) in 22 genes were genotyped for the patient and control groups.

A discussion of the optimal treatment of intracranial aneurysm rupture in elderly patients

C. Liu, “A discussion of the optimal treatment of intracranial aneurysm rupture in elderly patients”, vol. 13, pp. 6433-6438, 2014.

This study aimed to find an optimal treatment for intracranial aneurysm rupture in elderly patients. We adopted endovascular embolization and combined it with mini-invasive aspiration, vascular stenosis stenting, and rehabilitation training to treat 13 elderly patients with intracranial aneurysm rupture. When the 13 patients were discharged and evaluated by the Glasgow Outcome Score (GOS), 7 patients were grade 5, 4 patients were grade 4, and 2 patients were grade 2.

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