Interleukin-6

Endothelial cells on the proliferation and expression of intercellular adhesion molecule 1 and interleukin 8 of vascular smooth muscle cells

H. - P. Tang, Sun, L. - X., and Han, W., “Endothelial cells on the proliferation and expression of intercellular adhesion molecule 1 and interleukin 8 of vascular smooth muscle cells”, vol. 12, pp. 4363-4370, 2013.

The aim of this study was to investigate the influence of activated endothelial cells on the proliferation and secretion of vas­cular smooth muscle cells (VSMCs). Cultured lung microvascular endothelial cells were treated with or without tumor necrosis factor alpha (TNF-α; 10 ng/mL) for 6 h, and the supernatant was collected and filtered. The supernatant with TNF-α was called fluid A, and that without TNF-α was called fluid B.

Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population

S. Honsawek, Deepaisarnsakul, B., Tanavalee, A., Yuktanandana, P., Bumrungpanichthaworn, P., Malila, S., and Saetan, N., “Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population”, vol. 10, pp. 1674-1680, 2011.

Osteoarthritis is a chronic progressive degenerative joint disease characterized by age-related regressive change in articular cartilage. A single nucleotide polymorphism has been described at position -174 of the interleukin-6 (IL-6) promoter region, leading to three possible genotypes, GG, GC, and CC. We investigated a possible association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population. Genotype distributions and allelic frequencies of the IL-6 -174G/C polymorphism were investigated in 115 knee osteoarthritis patients and 100 healthy controls.

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