Interleukin 17

Inhibitory effect of microRNA-27b on interleukin 17 (IL-17)-induced monocyte chemoattractant protein-1 (MCP1) expression

K. D. Huang, Shen, Y., Wei, X., Zhang, F. Q., Liu, Y. Y., Ma, L., Huang, K. D., Shen, Y., Wei, X., Zhang, F. Q., Liu, Y. Y., and Ma, L., Inhibitory effect of microRNA-27b on interleukin 17 (IL-17)-induced monocyte chemoattractant protein-1 (MCP1) expression, vol. 15, p. -, 2016.

We investigated the effect of microRNA-27b (miR-27b), a gene expression regulatory factor, on the expression of monocyte chemoattractant protein-1 (MCP1) stimulated by interleukin 17 (IL-17). After IL-17 had been added to H9C2 cardiomyocytes, an miR-27b mimic was transfected into the H9C2 cells. The mRNA expression levels of miR-27b and MCP1 in the H9C2 cells were detected by SYBR green I fluorescence quantitative reverse transcription polymerase chain reaction. Enzyme-linked immunosorbent assay was used to measure the expression levels of MCP1 protein in the H9C2 cells.

Association between interleukin 17A gene polymorphisms and risk of coronary artery disease

X. S. Zheng, Wang, S., Ni, M., Zheng, X. S., Wang, S., and Ni, M., Association between interleukin 17A gene polymorphisms and risk of coronary artery disease, vol. 15, p. -, 2016.

Coronary artery disease (CAD) represents a leading cause of morbidity and mortality worldwide, and genetic factors contribute to the development of this disease. We conducted a case-control study to assess the association between interleukin 17A (IL17A) rs2275913 and rs3748067 polymorphisms and development of CAD. A total of 372 CAD patients and 372 healthy controls were recruited in our investigation between January 2013 and December 2014.

Stimulation of bacterial biofilms on Th17 immune cells

G. Q. Wang, Wang, L., Zhang, H. L., Dong, Y. Q., and Yang, Y. X., Stimulation of bacterial biofilms on Th17 immune cells, vol. 14, pp. 7721-7726, 2015.

We investigated the role of bacterial biofilms in stimulating T helper 17 (Th17) cells in infected organisms. The formation of bacterial biofilms isolated from clinical lavage fluid samples was measured. Th17 cells and interleukin 17 (IL-17) levels in the peripheral blood of healthy individuals, people infected by biofilm bacteria, people infected by non-biofilm bacteria, and in the lavage fluid from people infected by bacteria were determined. Differences in those data were tested using the SPSS 17.0 statistical software.

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