Interleukin-10

Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults

R. Hannum, Godoy, F. R., da Cruz, A. S., Vieira, T. C., Minasi, L. B., D. Silva, deM. e, da Silva, C. C., and da Cruz, A. D., Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults, vol. 14, pp. 17828-17833, 2015.

Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individual. In this study, we evaluated the single nucleotide polymorphism -1082G/A in the promoter region of interleukin-10 gene and its relationship with periodontal disease in Central Brazil.

Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm

F. Wang, Quan, Q. Q., Zhang, C. L., Li, Y. B., and Jiang, T. B., Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm, vol. 14, pp. 17599-17604, 2015.

In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age- and gender-matched healthy controls (N = 381) were collected between March 2012 and March 2014.

Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis

Y. - F. Yu, Han, Z. - G., Guo, W. - B., Zhang, G. - J., Yang, J. - K., Wu, F. - L., Ou, Q. - Y., Li, Y. - H., Cai, X. - Y., Zhan, Z. - N., Chen, J. - H., Xie, W. - L., Tang, L., and Liu, C. - D., Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis, vol. 14, pp. 18945-18957, 2015.

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort studies were quantitatively analyzed to evaluate IL-10 promoter gene polymorphisms and NPC risk.

Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia

Q. Y. Liu, Gao, F. Y., Liu, X. R., Li, J., Ji, M., Dong, J., and Wang, X. T., Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia, vol. 14, pp. 19323-19328, 2015.

In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in conformance with Hardy-Weinberg equilibrium (HWE; P = 0.46 and 0.17).

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