Insulin-like growth factors

Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population

Y. K. Wei, Ma, H. L., Guo, Y. Z., Yang, B. H., and Pang, W. X., Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population, vol. 14, pp. 14325-14330, 2015.

The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the study between 2012 and 2014. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype the rs35767 and rs972936 IGF-1 polymorphisms.

Association between polymorphisms in insulin-like growth factor-1 and risk of osteoporosis

W. Zhang, Zhang, L. C., Chen, H., Tang, P. F., and Zhang, L. H., Association between polymorphisms in insulin-like growth factor-1 and risk of osteoporosis, vol. 14, pp. 7655-7660, 2015.

We conducted a case-control study to assess the relation­ship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with osteoporosis were more likely to have drinking and smoking habits and have lower bone mineral density in the L2-L4 vertebrae, femoral neck, and total hip.

Expression profile of insulin-like growth factor system genes in muscle tissues during the postnatal development growth stage in ducks

C. - L. Song, Liu, H. - H., Kou, J., Lv, L., Li, L., Wang, W. - X., and Wang, J. - W., Expression profile of insulin-like growth factor system genes in muscle tissues during the postnatal development growth stage in ducks, vol. 12, pp. 4500-4514, 2013.

Insulin-like growth factors (IGFs) are regulators that modulate the proliferation and differentiation of muscle tissues. We quantified the messenger RNA (mRNA) expression of IGF-I, IGF-II, and type I and II IGF receptors (IGF-IR and IGF-IIR) in muscle tissues including the breast, leg, and myocardium during an early postnatal development growth stage (post-hatching weeks 1-8) in ducks. The results showed a significant age-related change in mRNA in these muscle tissues.

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