Inflammatory responses

Silencing effect of lentiviral vectors encod­-ing shRNA of Herp on endoplasmic reticulum stress and inflammatory responses in RAW 264.7 macrophages

F. L. Chen, Li, Q., Zhang, J. Y., Lei, L. J., Zhang, Z., Mahmoud, T. N., Wang, X. G., Lin, P. F., Jin, Y. P., and Wang, A. H., Silencing effect of lentiviral vectors encod­-ing shRNA of Herp on endoplasmic reticulum stress and inflammatory responses in RAW 264.7 macrophages, vol. 14, pp. 17587-17598, 2015.

Herp, a mammalian protein with a ubiquitin-like domain, can be strongly upregulated by endoplasmic reticulum (ER) stress during ER-associated protein degradation. However, the other cellular functions of Herp remain unclear. We explored the effect of Herp on ER stress and inflammatory responses in RAW 264.7 macrophages that had been exposed to tunicamycin or thapsigargin. We successfully constructed recombinant lentiviral vectors for Herp short-hairpin RNA (shRNA) expression to better understand the contribution made by Herp to other signaling pathways.

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