Inflammation

Correlation between adiponectin and hemorrhagic shock in mice

X. Gong, Liu, Y., Yao, S., Zheng, J. F., Wan, F., Xiang, X. D., Chai, X. P., Gong, X., Liu, Y., Yao, S., Zheng, J. F., Wan, F., Xiang, X. D., and Chai, X. P., Correlation between adiponectin and hemorrhagic shock in mice, vol. 15, p. -, 2016.

The aim of this study was to explore the relationship between adiponectin (ADPN) and hemorrhagic shock (HS) and the recovery after HS. This is significant for further understanding of the pathophysiological processes of HS and the development of better treatments. In total, 72 male C57BL/6 mice were assigned randomly to three groups: control, HS, and recovery (N = 24). The HS mouse model was constructed by hemorrhage of the carotid artery and recovery was achieved by tail vein injection of Ringer’s solution.

Protective effect of lyophilized recombinant human brain natriuretic peptide on renal ischemia/reperfusion injury in mice

X. Cao, Xia, H. Y., Zhang, T., Qi, L. C., Zhang, B. Y., Cui, R., Chen, X., Zhao, Y. R., and Li, X. Q., Protective effect of lyophilized recombinant human brain natriuretic peptide on renal ischemia/reperfusion injury in mice, vol. 14, pp. 13300-13311, 2015.

Brain natriuretic peptide (BNP) has a protective effect on acute injury of the heart, brain, and lung. However, its role in acute kidney injury (AKI) remains unclear. The aim of this study was to investigate the effect of lyophilized recombinant human BNP (lrh-BNP) on AKI and the underlying molecular mechanisms. An experimental model for AKI was established using an ischemia/reperfusion (I/R) procedure. Healthy adult BALB/c mice were randomized to the sham, I/R, and lrh-BNP-treated post-I/R (BNP + I/R) groups.

Effects of Danhong injection on hemodynamics and the inflammation-related NF-κB signaling pathway in patients with acute cerebral infarction

Y. Jiang and Lian, Y. J., Effects of Danhong injection on hemodynamics and the inflammation-related NF-κB signaling pathway in patients with acute cerebral infarction, vol. 14, pp. 16929-16937, 2015.

The objective of the current study was to investigate effects of Danhong injection on hemodynamics, inflammatory cytokines, and the NF-κB pathway in acute cerebral infarction. In total, 246 patients with acute cerebral infarction were divided into control (N = 121) and observation (N = 125) groups based on treatment. The control group underwent conventional treatment, while the observation group was treated with conventional medicine and Danhong injection.

Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults

R. Hannum, Godoy, F. R., da Cruz, A. S., Vieira, T. C., Minasi, L. B., D. Silva, deM. e, da Silva, C. C., and da Cruz, A. D., Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults, vol. 14, pp. 17828-17833, 2015.

Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individual. In this study, we evaluated the single nucleotide polymorphism -1082G/A in the promoter region of interleukin-10 gene and its relationship with periodontal disease in Central Brazil.

Protective effect and mechanism of probucol in the treatment of spinal cord injury

W. B. Zhu, Wang, Y. H., Sun, G. F., and Wu, J. H., Protective effect and mechanism of probucol in the treatment of spinal cord injury, vol. 14, pp. 8029-8037, 2015.

To investigate the effects of probucol on the treatment of spinal cord injury in rat, 80 rats were randomly divided into two groups of 40: a group treated with probucol and a control group. Allen’s method was used to establish a rat model of spinal cord injury. After establishment, probucol (500 mg·kg-1·day-1) was intraperitoneally injected into the treatment group rats for 1 week, while the same amount of saline was used to treat the control group.

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