Immune system

Relationship of common expression quantitative trait loci genes to the immune system

J. Li, Wang, L., Li, H., Zhang, R., Li, X., and Guo, M., Relationship of common expression quantitative trait loci genes to the immune system, vol. 12, pp. 6546-6553, 2013.

Tissue-specific expression quantitative trait loci (eQTLs) are always linked to specific diseases. In this study, we focused on eQTLs common to multiple tissues and explored their functional mechanisms in disease for the first time. We found 11 common eQTL genes among multiple tissues. Five genes were validated through a genome-wide association study, 3 genes were validated using the Online Mendelian Inheritance in Man database, and the others were validated through text mining. Most of these disorders were related to the systemic immune system.

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