IL-6

Effect of total peony glucoside pretreatment on NF-κB and ICAM-1 expression in myocardial tissue of rat with myocardial ischemia-reperfusion injury

L. Lu, Wei, P., Cao, Y., Zhang, Q., Liu, M., Liu, X. D., Wang, Z. L., Zhang, P. Y., Lu, L., Wei, P., Cao, Y., Zhang, Q., Liu, M., Liu, X. D., Wang, Z. L., and Zhang, P. Y., “Effect of total peony glucoside pretreatment on NF-κB and ICAM-1 expression in myocardial tissue of rat with myocardial ischemia-reperfusion injury”, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

Fast, effective recovery of the coronary blood flow, after myocardial ischemia, is an effective method to treat this ischemia. However, myocardial ischemia-reperfusion (I/R) can aggravate ischemia-induced cardiac dysfunction and myocardial cell damage, leading to intracellular calcium overload, apoptosis, and inflammation. Therefore, clarifying its mechanism is important for the prevention of myocardial I/R injury.

Significance of TNF-α and IL-6 expression in invasive pituitary adenomas

J. L. Wu, Qiao, J. Y., Duan, Q. H., Wu, J. L., Qiao, J. Y., Duan, Q. H., Wu, J. L., Qiao, J. Y., and Duan, Q. H., “Significance of TNF-α and IL-6 expression in invasive pituitary adenomas”, vol. 15, p. -, 2016.

The aim of this study was to investigate expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-α and IL-6 were found to be upregulated in IPA tissue compared with that of NIPA (P

Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis

X. F. Jin, Wang, D. L., Zhou, Y., and Xiong, H., “Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis”, vol. 14, pp. 13076-13083, 2015.

Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were retrieved. Pooled ORs with 95%CIs were calculated using fixed- or random-effect models.

Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

R. Mde Albuque Maranhão, Esteves, F. A. Martins, Crovella, S., Segat, L., and Souza, P. R. Eleutério, “Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients”, vol. 14, pp. 16343-16352, 2015.

The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibility to CD. A case-control of 192 patients with CD (96 DQ2-positive and 96 DQ8-positive) and 96 healthy controls from northeast Italy were included in the study.

Diagnostic values of microRNA-31 in peripheral blood mononuclear cells for pediatric pulmonary tuberculosis in Chinese patients

J. X. Wang, Xu, J., Han, Y. F., Zhu, Y. B., and Zhang, W. J., “Diagnostic values of microRNA-31 in peripheral blood mononuclear cells for pediatric pulmonary tuberculosis in Chinese patients”, vol. 14, pp. 17235-17243, 2015.

We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People’s Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in parallel, served as the control group. Real-time PCR was used to detect miR-31 expression in PBMCs. Serum levels of IL-6, TNF-α, NF-κB, and IFN-γ was detected by ELISA.

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