IL-6

Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors

B. X. Ren, Ji, Y., Tang, J. C., Sun, D. P., Hui, X., Yang, D. Q., and Zhu, X. L., Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors, vol. 14, pp. 2133-2138, 2015.

The study aimed to investigate the effect of intrathecal injections of Tanshinone IIA on thermal hyperalgesia in a mouse model of bone cancer-pain. Spinal IL-1β, IL-6, TNF-α expression levels were analyzed. C3H/HeNCrlVr male mice were assigned to groups that either received dose-dependent injections of Tanshinone IIA, or the DMSO + Sham, Tanshinone IIA + Sham, DMSO + Tumor, and Control groups. Paw withdrawal thermal latency (PWTL) was measured with a radiant heat stimulus and mRNA expression levels were determined using real-time PCR.

Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis

Y. Song, Gu, H. D., He, Y., and Wang, J. W., Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis, vol. 14, pp. 2631-2637, 2015.

We aimed to investigate the role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Blood samples were collected from 216 patients receiving hemodialysis treatment. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype IL-6 -634C/G, -174G/C and -572C/G. By multivariate analysis, we found that the IL-6 -634GG genotype was associated with increased risk of cardiovascular events in patients receiving hemodialysis, with HR (95%CI) of 4.07 (1.20-15.70).

-174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race

S. Mandal, Abebe, F., and Chaudhary, J., -174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race, vol. 13, pp. 139-151, 2014.

Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism. The -174G>C/rs1800795 polymorphism in the IL-6 promoter is functionally relevant in terms of transcriptional regulation and disease association.

Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in

P. N. Mukhopadhyaya, Acharya, A., Chavan, Y., Purohit, S. S., and Mutha, A., Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in, vol. 9, pp. 2060-2068, 2010.

A population-based study was undertaken to evaluate linkage between single-nucleotide polymorphisms known as risk factors and type 2 diabetes in an Indian population. The study population was comprised of 40 normal glucose-tolerant individuals (21 males and 19 females) and 40 type 2 diabetes patients (21 males and 19 females). The genes and their corresponding single-nucleotide polymorphisms that we screened were VDR (rs 731236 and rs 1544410), IL-6 (rs 1800795), TCF7L2 (rs 7903146) and TNF-α (rs 1800629).

Cox-2 gene polymorphism and IL-6 levels in coronary artery disease

K. K. Ol, Agachan, B., Gormus, U., Toptas, B., and Isbir, T., Cox-2 gene polymorphism and IL-6 levels in coronary artery disease, vol. 10, pp. 810-816, 2011.

Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now known to be an inflammatory process mediated by prostaglandins and several interleukins. As both are important in inflammatory processes, we examined Cox-2 (-765G > C) polymorphism and interleukin-6 levels in coronary artery disease patients compared to healthy controls.

Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice

R. L. Sun, Wang, H. Y., Yang, X. Y., Sheng, Z. J., Li, L. M., Wang, L., Wang, Z. G., and Fei, J., Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice, vol. 10, pp. 3712-3721, 2011.

Zinc finger protein 191, ZNF24 and Zfp191 in both humans and mice belong to the SCAN domain subfamily of Krüppel-like zinc finger transcription factors. Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, little is known about its target genes or its role in other physiological and pathological processes. We have identified the putative target genes of Zfp191, using an in silico genome-wide scan.

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