Hypoxia

Protective effect of lyophilized recombinant human brain natriuretic peptide on renal ischemia/reperfusion injury in mice

X. Cao, Xia, H. Y., Zhang, T., Qi, L. C., Zhang, B. Y., Cui, R., Chen, X., Zhao, Y. R., and Li, X. Q., Protective effect of lyophilized recombinant human brain natriuretic peptide on renal ischemia/reperfusion injury in mice, vol. 14, pp. 13300-13311, 2015.

Brain natriuretic peptide (BNP) has a protective effect on acute injury of the heart, brain, and lung. However, its role in acute kidney injury (AKI) remains unclear. The aim of this study was to investigate the effect of lyophilized recombinant human BNP (lrh-BNP) on AKI and the underlying molecular mechanisms. An experimental model for AKI was established using an ischemia/reperfusion (I/R) procedure. Healthy adult BALB/c mice were randomized to the sham, I/R, and lrh-BNP-treated post-I/R (BNP + I/R) groups.

Subscribe to Hypoxia