Hypothermia

Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury

P. Zhu, Zhao, M. Y., Li, X. H., Fu, Q., Zhou, Z. F., Huang, C. F., Zhang, X. S., Huang, H. L., Tan, Y., Li, J. X., Li, J. N., Huang, S., Ashraf, M., Lu, C., Chen, J. M., Zhuang, J., and Guo, H. M., “Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury”, vol. 14, pp. 10490-10499, 2015.

We evaluated changes in BAX and BCL2 expression levels after spinal cord ischemia/reperfusion injury (SCII) and hypothermia during operations in rats. Eighty rats were divided into four groups: Group A (N = 20, 18°C); Group B (N = 20, 28°C); Group C (N = 20, room temperature); and Group D (N = 20, sham operation control). Spinal cord ischemia was induced for 90 min. Hypothermia was induced 15 min before, and maintained during ischemia, followed by heating to normothermia for 30 min after reperfusion.

Changes in hippocampal ultrastructure and vimentin expression in rhesus monkeys following selective deep hypothermia and blood occlusion

B. C. Li, Fu, X., Niu, X. Q., Fan, Y. D., Xu, W., Zhao, X. X., and Pu, J., “Changes in hippocampal ultrastructure and vimentin expression in rhesus monkeys following selective deep hypothermia and blood occlusion”, vol. 14, pp. 651-658, 2015.

Previous studies have shown that selective cerebral profound hypothermia combined with antegrade cerebral perfusion can improve resistance to cerebral hypoxia-ischemia in monkeys. The aim of this study was to observe the effect of selective cerebral profound hypothermia on the ultrastructure and vimentin expression in monkey hippocampi after severe cerebral ischemia. Eight healthy adult rhesus monkeys were randomly divided into two groups: profound hypothermia (N = 5) and normothermia (N = 3).

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