Hypertension

Molecular characterization of a Han Chinese family with essential hypertension

J. F. Zhu, Zhang, X., Ling, L., Zhu, J. F., Zhang, X., and Ling, L., Molecular characterization of a Han Chinese family with essential hypertension, vol. 15, p. -, 2016.

Mutations in the mitochondrial genome have been found to be associated with essential hypertension. Here, we report the clinical and molecular characterization of a three-generation Han Chinese family with maternally inherited hypertension. Most strikingly, this pedigree exhibited a high penetrance of hypertension. Sequence analysis of the mitochondrial genome showed the presence of a homoplasmic T16189C mutation in the D-loop and the intergenic CO2/tRNALys 9-bp common deletion, as well as a set of polymorphisms belonging to the East Asia haplogroup B5b1.

Serum soluble RAGE level inversely correlates with left ventricular hypertrophy in essential hypertension patients

Q. Liu, Chen, H. B., Luo, M., Zheng, H., Liu, Q., Chen, H. B., Luo, M., and Zheng, H., Serum soluble RAGE level inversely correlates with left ventricular hypertrophy in essential hypertension patients, vol. 15, p. -, 2016.

Soluble receptor for advanced glycation end-products (sRAGE) acts as a decoy to prevent interaction between RAGE and its pro-inflammatory ligands. sRAGE levels have been found to decrease in chronic inflammatory diseases, including hypertension. However, few data have been reported concerning the association between serum sRAGE levels and hypertensive left ventricular hypertrophy (LVH). Fasting blood samples were obtained from 209 essential hypertensive patients, and sRAGE levels were measured using a commercially available double-sandwich enzyme-linked immunosorbent assay kit.

Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon

S. M. Ghogomu, Ngolle, N. E., Mouliom, R. N., Asa, B. F., Ghogomu, S. M., Ngolle, N. E., Mouliom, R. N., Asa, B. F., Ghogomu, S. M., Ngolle, N. E., Mouliom, R. N., and Asa, B. F., Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon, vol. 15, p. -, 2016.

The association of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and essential hypertension has been reported but with controversial results in diverse populations in Asia and Europe, thereby suggesting a dependency on ethnicity. The aim of this study was to investigate the association between the MTHFR C677T polymorphism and essential hypertension in a Cameroonian population (Bantu ethnic group) of the South West Region.

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