Hyperphosphatemia

Effect of hyperphosphatemia on gene expression of the Na-Pi cotransporter in rats

C. Zhang, Shi, L. - M., Li, Y., Zhu, Q. - G., Jin, C. - L., Wang, H. - P., Zhou, L., Hu, X. - P., Zhang, L., Wang, H., Yuan, G. - J., Xu, L., Zhao, Y. - K., and Chou, Y., Effect of hyperphosphatemia on gene expression of the Na-Pi cotransporter in rats, vol. 14, pp. 19404-19410, 2016.

We investigated the effect of high phosphorus content on the sodium-phosphate cotransporter (NaPi-IIa and NaPi-IIl). Forty-eight Sprague-Dawley rats were divided into 3 groups: high-phosphorus group (HP) with fructose diphosphate sodium injection; self-manufactured low-phosphorus diet group (LP); and normal diet group (NP). At the 1st, 2nd, 4th, and 6th weeks, 4 rats from each group were sacrificed for detecting serum levels of calcium, phosphorus, and intact parathyroid hormone.

Establishment and characterization of a rat model of hyperphosphatemia

C. Zhang, Shao, Y., Zhu, Q. - G., Li, Y., Jin, C. - L., Wang, H. - P., Zhou, L., Yu, C., Zhao, Y. K., Yuan, G. J., Hu, X. - P., Zhang, L., and Wang, H., Establishment and characterization of a rat model of hyperphosphatemia, vol. 14, pp. 11089-11098, 2015.

We established a rat model of hyperphosphatemia and investigated the systemic effects of high phosphorus (P). Sprague Dawley rats were randomly divided into high (HP), low (LP), and normal (NP) P groups (N = 12 each), which received injections of fructose diphosphate sodium, or were fed self-manufactured low phosphorus or normal diets, respectively. In each group, 4 rats were sacrificed at the first, third, and sixth week to detect the serum (Scr) and urinary creatinine and P, and calcium (Ca) levels.

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