Hydropathy

HydroCalc Proteome: a tool to identify distinct characteristics of effector proteins

G. J. da Silva, da Silva, R. G. T. M., Silva, V. A., Caritá, E. C., Fachin, A. L., Marins, M., da Silva, G. J., da Silva, R. G. T. M., Silva, V. A., Caritá, E. C., Fachin, A. L., and Marins, M., HydroCalc Proteome: a tool to identify distinct characteristics of effector proteins, vol. 15, p. -, 2016.

Bacterial pathogenicity is associated with secretion of effector proteins into intra- and extracellular spaces. These proteins interfere with cellular processes such as inhibition of phagosome-lysosome fusion, induction of apoptosis and autophagy, activation and suppression of kinases, regulation of receptor activity, and modulation of transcription factors. Knowledge regarding the characteristics of these proteins would assist in pathogenicity studies, and help to identify possible and novel targets for antibacterial drugs.

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