Hydrogen

Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis

L. - D. Liu, Wu, X. - Y., Tao, B. - D., Wang, N., Zhang, J., Liu, L. - D., Wu, X. - Y., Tao, B. - D., Wang, N., Zhang, J., Liu, L. - D., Wu, X. - Y., Tao, B. - D., Wang, N., and Zhang, J., “Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis”, vol. 15, p. -, 2016.

This study aimed to explore the protective effect of hydrogen and to investigate the underlying mechanism of its preliminary effect on the alveolar epithelial barrier function in septic rats. Forty-five male Sprague-Dawley rats were divided randomly into three groups (N = 15): control [saline injection (intraperitoneal, ip), air drawing; SA], acute lung injury group [lipopolysaccharide (LPS) injection (ip, 15 mg/kg), air drawing; LA], and acute lung injury combined with hydrogen drawing group [LPS injection (ip, 15 mg/kg), 2% hydrogen drawing; LH].

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin

Y. Yu, Wang, W. N., Han, H. Z., Xie, K. L., Wang, G. L., and Yu, Y. H., “Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin”, vol. 14, pp. 6202-6212, 2015.

We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H2, LPS, LPS+H2, H2, and LPS+H2 in saturated hydrogen-rich medium.

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