Changes of gene expression profiles across different phases of vascular calcification in rats
“Changes of gene expression profiles across different phases of vascular calcification in rats”, vol. 12, pp. 5945-5957, 2013.
, This study investigated the alteration of gene expression profiles in order to gain a deeper understanding into the molecular mechanism involved in different processes of vascular calcification (VC). Sprague Dawley (SD) rats were injected with 300,000 μg/kg vitamin D3 and gavaged with 25 mg/kg nicotine for 8 or 16 weeks to create 8- and 16-week VC calcification groups. Histological analysis and quantification of aortic calcium content were used to determine the severity of vascular calcification.