Hybridizations

Changes of gene expression profiles across different phases of vascular calcification in rats

Z. M. Jiang, Wu, X. J., Liu, Y., Du, X. H., Shen, S. J., Xu, L. Y., and Sun, W. X., Changes of gene expression profiles across different phases of vascular calcification in rats, vol. 12, pp. 5945-5957, 2013.

This study investigated the alteration of gene expression profiles in order to gain a deeper understanding into the molecular mechanism involved in different processes of vascular calcification (VC). Sprague Dawley (SD) rats were injected with 300,000 μg/kg vitamin D3 and gavaged with 25 mg/kg nicotine for 8 or 16 weeks to create 8- and 16-week VC calcification groups. Histological analysis and quantification of aortic calcium content were used to determine the severity of vascular calcification.

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