Human papillomavirus

Characterization of gene methylation in human papillomavirus associated-head and neck squamous cell carcinoma

H. Z. Zhang, Shan, C. G., Huang, A. P., Wang, J. M., Zhang, H. Z., Shan, C. G., Huang, A. P., and Wang, J. M., “Characterization of gene methylation in human papillomavirus associated-head and neck squamous cell carcinoma”, vol. 15, p. -, 2016.

Head and neck squamous cell carcinoma (HNSCC) has become one of the most common forms of cancer worldwide. Hypermethylation-induced silencing of tumor-associated gene has been proposed as an important cofactor in cancer pathology. This paper aimed to characterize the gene methylation patterns in human papillomavirus (HPV) associated-HNSCC. TIMP3 and APC methylation status in neoplastic (N = 92) and non-neoplastic tissues (N = 92) of HNSCC as well as their association with HPV infection were investigated via methylation-specific PCR assays.

Prevalence of human papillomavirus (HPV), distribution of HPV types, and risk factors for infection in HPV-positive women

M. V. C. Santos Filho, Gurgel, A. P. A. D., Lobo, C. D. P., Freitas, A. C. F., Silva-Neto, J. C., Silva, L. A. F., Filho, M. V. C. Santos, Gurgel, A. P. A. D., Lobo, C. D. P., Freitas, A. C. F., Silva-Neto, J. C., and Silva, L. A. F., “Prevalence of human papillomavirus (HPV), distribution of HPV types, and risk factors for infection in HPV-positive women”, vol. 15, p. -, 2016.

The aim of this study was to describe the prevalence of human papillomavirus (HPV), the distribution of different HPV types, and the putative risk factors for infection among HPV-positive women from the State of Alagoas, Northeast Brazil. We analyzed data from 515 patients attending public and private health centers. HPV DNA from cervical samples was extracted and HPV genotyping was performed by polymerase chain reaction using MY09/11 consensus primers followed by direct sequencing.

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