Human leukocyte antigen

Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing spondylitis

H. - Y. Zou, Yu, W. - Z., Wang, Z., He, J., and Jiao, M., “Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing spondylitis”, vol. 14, pp. 5652-5657, 2015.

We investigated the distribution of human leukocyte antigen (HLA)-B27 subtypes in Uygur ankylosing spondylitis patients in Xinjiang. B27-positive patients with ankylosing spondylitis were subtyped by using polymerase chain reaction-sequence-based typing. The HLA-B27 subtype frequencies of Uygur patients were compared with those in Han patients in Xinjiang and the other areas of China. B*2705 was the predominant subtype in Uygur patients with a frequency of 58.95%, which was much higher than that in Han patients in Xinjiang (31.58%, P

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

L. Yang, Wang, L. J., Shi, G. L., Ni, L., Song, C. X., Zhang, Z. X., and Xu, S. F., “Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer”, vol. 9, pp. 750-755, 2010.

The primary function of the human leukocyte antigen (HLA) system is to regulate the immune response. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-A, B and DRB1 alleles in 100 unrelated patients with lung carcinoma and in 438 unrelated normal controls of Han nationality from North China, using sequence-based typing and PCR with sequence-specific primers.

Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients

G. L. Shi, Hu, X. L., Yang, L., Rong, C. L., Guo, Y. L., and Song, C. X., “Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients”, vol. 10, pp. 1331-1336, 2011.

Human leukocyte antigen (HLA) plays a central role in the regulation of the immune response. HLA class II molecules are essential for T cell-mediated adaptive immunity and present peptide antigens to CD4⁺ T cells. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases.

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

D. Wu, Wu, Y., Liu, J. L., Wang, B., and Zhang, X. D., “Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis”, vol. 10, pp. 3109-3120, 2011.

Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled odds ratio (OR) and 95% confidence interval (95%CI).

Human leukocyte antigen