HS-40

Regulation of human alpha-globin gene expression and alpha-thalassemia

D. M. Ribeiro and Sonati, M. F., Regulation of human alpha-globin gene expression and alpha-thalassemia, vol. 7. pp. 1045-1053, 2008.

Hemoglobin and globin genes are important models for studying protein and gene structure, function and regulation. We reviewed the main aspects of regulation of human α-globin synthesis, encoded by two adjacent genes (α2 and α1) clustered on chromosome 16. Their expression is controlled mainly by a regulatory element located 40 kb upstream on the same chromosome, the α-major regulatory element, whose activity is restricted to a core fragment of 350 bp, within which several regulatory protein binding sites have been found.

Subscribe to HS-40