HLA-G

HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis

A. V. C. Coelho, Moura, R. R., Crovella, S., Celsi, F., Coelho, A. V. C., Moura, R. R., Crovella, S., and Celsi, F., HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis, vol. 15, p. -, 2016.

Human leukocyte antigen (HLA)-G is a key tolerogenic molecule mainly expressed in the placenta and is crucial for implantation of the embryo and immunological tolerance of the fetus during pregnancy. However, under pathological conditions, such as cancer or viral infections, HLA-G can be expressed in other tissues. The gene coding for HLA-G (HLA-G, chromosome 6p21.3) presents numerous polymorphisms, some of them influencing its expression. One of the most studied, is the 14 bp ins/del (rs371194629) situated at the 3'-UTR of the gene.

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