Histone acetylation

Position effect variegation and epigenetic modification of a transgene in a pig model

Z. Yin, Kong, Q. R., Zhao, Z. P., Wu, M. L., Mu, Y. S., Hu, K., and Liu, Z. H., Position effect variegation and epigenetic modification of a transgene in a pig model, vol. 11, pp. 355-369, 2012.

Sequences proximal to transgene integration sites are able to regulate transgene expression, resulting in complex position effect variegation. Position effect variegation can cause differences in epigenetic modifications, such as DNA methylation and histone acetylation. However, it is not known which factor, position effect or epigenetic modification, plays a more important role in the regulation of transgene expression.

Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases

Y. Q. Liu, Tao, D. C., Liao, S. Y., Yang, Y., Ma, Y. X., and Zhang, S. Z., Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases, vol. 12, pp. 4060-4069, 2013.

Multiple genes are restrictively expressed in mammalian testicular tissues, and they play important roles in the complex process of spermatogenesis. Investigation of these genes and their expression regulation mechanisms is valuable to elucidate the molecular process of spermatogenesis. In this study, we identified a novel human gene, ring finger protein 148 (RNF148) that is abundantly expressed in testes and slightly expressed in pancreas.

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