High mobility group box 1

Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis

S. Y. Wang, Li, Z. J., Wang, X., Li, W. F., and Lin, Z. F., Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis, vol. 14, pp. 4344-4353, 2015.

The aim of this study was to investigate the influence of ulinastatin (UTI) on high mobility group box 1 (HMGB1), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 expression in acute lung injury (ALI) rats with sepsis caused by cecal ligation and puncture (CLP) surgery, as well as to examine the underlying biological mechanism. Thirty rats were randomly and evenly divided into sham (control), CLP, and CLP + UTI groups.

Expression of high-mobility group box protein 1 in diabetic foot atherogenesis

C. F. Tsao, Huang, W. T., Liu, T. T., Wang, P. W., Liou, C. W., Lin, T. K., Hsieh, C. J., and Weng, S. W., Expression of high-mobility group box protein 1 in diabetic foot atherogenesis, vol. 14, pp. 4521-4531, 2015.

The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabetic patients, including 29 patients with PAOD, who had undergone amputation for diabetic foot and 7 nondiabetic patients who had undergone amputation after traumatic injury.

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