Hepcidin

Molecular cloning and mRNA expression of a hepcidin gene from the spinyhead croaker, Collichthys lucidus

C. Sang, Lin, Y., Jiang, K., Zhang, F., and Song, W., Molecular cloning and mRNA expression of a hepcidin gene from the spinyhead croaker, Collichthys lucidus, vol. 14, pp. 16050-16059, 2015.

Antimicrobial peptides are important components that participate in host innate immune activities and play crucial roles in host defense against microbial invasion. Hepcidin is an antimicrobial peptide and iron-regulatory molecule that primarily functions in the liver. In the present study, we first obtained a full-length cDNA sequence of hepcidin and its corresponding genomic DNA sequence from Collichthys lucidus using RT-PCR and rapid amplification of cDNA ends (RACE), and then analyzed these sequences using bioinformatics software. The results showed that C.

Correlation between hepcidin level and renal anemia

L. - N. Yang, Zhang, P., Tang, F., Wang, G., and Li, F. - E., Correlation between hepcidin level and renal anemia, vol. 13, pp. 7407-7410, 2014.

Anemia in patients with chronic renal insufficiency (CRI) is related to the chronic inflammatory state, low iron absorption rate, and low utilization rate. As a key protein for iron metabolism, hepcidin plays an important role in CRI anemia. The study aimed to determine the correlation between hepcidin level and renal anemia.

Serum hepcidin level and its clinical significance in maintenance hemodialysis patients

P. Zhang, Yang, L. - N., Wang, G., Li, F. - E., and Tang, F., Serum hepcidin level and its clinical significance in maintenance hemodialysis patients, vol. 13, pp. 9883-9888, 2014.

Hepcidin is a key protein of iron metabolism, which may play an important role in the prognosis of patients with chronic renal failure on maintenance hemodialysis. The purpose of this study was to investigate the relationship between the prognosis of maintenance hemodialysis patients and serum hepcidin level. We enrolled 60 patients on maintenance hemodialysis and 30 healthy controls from March 2012 to December 2012 in our hospital. Peripheral blood samples were collected to determine hepcidin by an ELISA method.

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