Hepatocellular carcinoma

Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma

L. L. Chen, Shen, Y., Zhang, J. B., Wang, S., Jiang, T., Zheng, M. Q., Zheng, Z. J., Chen, C. X., Chen, L. L., Shen, Y., Zhang, J. B., Wang, S., Jiang, T., Zheng, M. Q., Zheng, Z. J., and Chen, C. X., Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma, vol. 15, p. -, 2016.

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. MicroRNA-34 (miR-34) gene plays a key role in altering the apoptotic cycle and pathways of downstream cells, and therefore influences carcinogenesis. In this case-control study, we assessed the role of the pri-miR-34b/c rs4938723 polymorphism in HCC risk. The pri-miR-34b/c polymorphic genotype was determined in 286 patients with HCC and 572 controls using polymerase chain reaction-restriction fragment length polymorphism.

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