Hepatocellular carcinoma

Significant association between the MTHFR A1298C polymorphism and hepatocellular carcinoma risk: a meta-analysis

W. Chang, Meng, Q., Liu, J. H., Wu, L. X., Chen, Y., and Chen, S. D., Significant association between the MTHFR A1298C polymorphism and hepatocellular carcinoma risk: a meta-analysis, vol. 14, pp. 15972-15980, 2015.

The A1298C polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be associated with hepatocellular carcinoma (HCC), but there are conflicting results from previous studies. The present study aimed to investigate the association between this polymorphism and the risk of HCC using a meta-analysis of the published studies. Published literature from PubMed and Embase databases was systematically searched to identify relevant studies before October 2014. The Begg test was used to measure publication bias.

DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis

R. B. Ji, Qian, Y. S., Hu, A. R., and Hu, Y. R., DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis, vol. 14, pp. 15988-15996, 2015.

Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association between this polymorphism and HCC risk in the Chinese population.

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