Hepatitis B virus

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

M. W. Peng, Lu, S. Q., Liu, J., Dong, C. Y., Peng, M. W., Lu, S. Q., Liu, J., Dong, C. Y., Peng, M. W., Lu, S. Q., Liu, J., and Dong, C. Y., “Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma”, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism assay was applied to assess the sequence variants of interest.

Detection of serum anti-melanocyte antibodies and identification of related antigens in patients with vitiligo

M. C. Zhu, Liu, C. G., Wang, D. X., and Zhan, Z., “Detection of serum anti-melanocyte antibodies and identification of related antigens in patients with vitiligo”, vol. 14, pp. 16060-16073, 2015.

We detected autoantibodies against melanocytes in serum samples obtained from 50 patients, including 4 with HBV, with vitiligo and identified the associated membrane antigens. Heat shock protein 70 (HSP70) and anti-tyrosinase-related protein 1 (TRP-1) antibody levels were analyzed. The associated antigens in normal human melanocyte were identified by immunofluorescence. Autoantibodies against melanocyte membrane and cytoplasmic proteins were detected by western blot. Membrane antigens with higher frequencies were identified by protein mass spectrometry.

Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo

Y. B. Deng, Qin, H. J., Luo, Y. H., Liang, Z. R., and Zou, J. J., “Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo”, vol. 14, pp. 10087-10095, 2015.

We investigated the effects of hepatitis B virus (HBV) S/C double gene loci antisense locked nucleic acid on replication and expression of HBV in hepatitis transgenic mice. HBV mice (N = 30) were randomly divided into five groups of six mice: 5% glucose solution control, empty liposome control, single-target S, single-target C, and dual-target SC groups. An antisense locked nucleic acid fragment was injected into the mice.

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