Hepatitis B virus

Identification of a mutation in Hepatitis B virus surface antigen capable of evading ELISA screening

Y. Cui, Zhang, T., Yan, Y., Liu, K., Cui, Y., Zhang, T., Yan, Y., and Liu, K., “Identification of a mutation in Hepatitis B virus surface antigen capable of evading ELISA screening”, vol. 15, p. -, 2016.

Hepatitis B virus (HBV) infection can cause HBV-related cirrhosis, liver failure, and hepatocellular carcinoma. At present, a hepatitis B surface antigen (HBsAg) blood test is the primary clinical and diagnostic marker for the identification of a chronic HBV infection. In the current study, we isolated a novel HBV mutant from a chronic HBV patient, capable of causing a false negative test result for most (7 of 8) commercial HBsAg ELISA kits.

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

M. W. Peng, Lu, S. Q., Liu, J., Dong, C. Y., Peng, M. W., Lu, S. Q., Liu, J., Dong, C. Y., Peng, M. W., Lu, S. Q., Liu, J., and Dong, C. Y., “Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma”, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism assay was applied to assess the sequence variants of interest.

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