Hepatitis B virus

Identification of a mutation in Hepatitis B virus surface antigen capable of evading ELISA screening

Y. Cui, Zhang, T., Yan, Y., Liu, K., Cui, Y., Zhang, T., Yan, Y., and Liu, K., Identification of a mutation in Hepatitis B virus surface antigen capable of evading ELISA screening, vol. 15, p. -, 2016.

Hepatitis B virus (HBV) infection can cause HBV-related cirrhosis, liver failure, and hepatocellular carcinoma. At present, a hepatitis B surface antigen (HBsAg) blood test is the primary clinical and diagnostic marker for the identification of a chronic HBV infection. In the current study, we isolated a novel HBV mutant from a chronic HBV patient, capable of causing a false negative test result for most (7 of 8) commercial HBsAg ELISA kits.

Identifying significant pathways of hepatitis B virus-related hepatocellular carcinoma based on crosstalk and network pathways

L. M. Wen, Wu, W. Z., Peng, X. C., Wen, L. M., Wu, W. Z., and Peng, X. C., Identifying significant pathways of hepatitis B virus-related hepatocellular carcinoma based on crosstalk and network pathways, vol. 15, p. -, 2016.

This study aims to identify significant pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) based on the pathway network strategy. We proposed a pathway network where a protein-protein interaction (PPI) network was integrated with the crosstalk of pathways. Pathway data were first obtained from background PPI network, Reactome pathway database, and common genes between mRNA differentially expressed genes (DEGs), and miRNA target genes of HBV-related HCC.

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